Effects from Contact Area of the Instrument Causing Trauma on Skull Fracture in Rabbits / 医用生物力学

Objective To explore the effects from different contact areas of the instrument causing trauma on biomechanical response parameters of rabbit skull fractures under quasi-static compression conditions. Methods The rabbits were divided into the scalp preservation group and scalp removal group. Each group was subdivided into 3 mm group, 6 mm group, 9 mm group according to contact diameter of the instrument causing trauma. There were 9 rabbits in each group, 54 rabbits in total. All rabbits were put to death by over anesthesia and made into a skull compression model. An electronic universal material testing machine was used to perform quasi-static compression of rabbit skulls to fractures, and biomechanical response parameters such as ultimate load, deformation under ultimate load and compressive strength of rabbit skulls in each group were detected. Results The differences in ultimate load, deformation under ultimate load, and compressive strength of rabbit skulls in scalp preservation group and scalp removal group under different contact areas were statistically significant. The ultimate load was positively correlated with the contact area, and the compressive strength was negatively correlated with the contact area. No correlation was found between deformation under ultimate load and contact area. For scalp preservation group and scalp removal group, the difference in deformation under ultimate load was statistically significant in the 3 mm contact surface diameter group, and there was no statistical significance in the other groups. Conclusions The contact area is positively correlated with the ultimate load of rabbit skull fracture and negatively correlated with compressive strength, while it has no correlation with deformation under ultimate load and is unrelated to whether the scalp is removed.

Clinical effect of different scheme of moxifloxacin and levofloxacin for elderly multi drug resistant pulmonary tuberculosis / 中国基层医药

Objective To explore the clinical effect of different scheme of moxifloxacin and levofloxacin for elderly multi drug resistant pulmonary tuberculosis.Methods 136 cases of elderly patients included in the study were randomly divided into the observation group 1 and observation group 2 with 68 cases in each group according to the sequence in group.The observation group 1 used moxifloxacin regimen for treatment of pulmonary tuberculosis while the observation group 2 used levofloxacin regimen.The two groups were treated for 18 months and observed the clinical curative effect,and the sputum negative,pulmonary lesions absorption,empty changes and adverse reactions.Results The total efficiency of the observation group 1 was 92.6％,which in the observation group 2 was 72.1％,the total efficiency of the two groups had a significant difference (x2 =9.917,P =0.002) ;the sputum negative conversion rate of the observation group 1 at the end of 3 months was significantly higher than that of the observation group 2 (x2 =4.115,P =0.043),no significant difference was found at the other time points (all P ＞ 0.05) ; after treatment,the obvious absorption + absorption of lung lesion in the observation group 1 was 59 cases,accounting for 86.8％,that in observation group 2 was 48 cases,accounting for 70.6％,two groups of lung lesions absorption had significant difference (x2 =5.303,P =0.021) ; the pulmonary cavity closure + reduced in the observation group 1 was 52 cases,accounting for 76.4％,that in the observation group 2 was 41 cases,accounting for 60.3％,with significant difference between the two groups (x2 =4.115,P =0.043) ;there was no significant difference in adverse reaction of the two groups (P ＞ 0.05).Conclusion Moxifloxacin anti tuberculosis regimen has a better curative effect in treatment of elderly patients with multi drug resistant pulmonary tuberculosis,which should be expanded the application.

Performance verification of electrochemical luminescence detection reagents of HBV serological markers / 国际检验医学杂志

Objective To verify the performance of HBV detection reagents for Roche MODULRA E170 electrochemical lumi-nescence analyzer .Methods Referring to CLSI EP15-A document ,the minimum detection limit ,linear range ,precision and accuracy of the HBV detection reagents were verified .Results The intra-assay coefficient of variation ,total coefficient of variation ,linear range of HBsAb ,and minimum detection limits of HBsAg and HBeAg of the HBV detection reagents for MODULRA E170 electro-chemical luminescence analyzer all reached the performance claimed by manufacturer .Conclusion The performance of HBV detec-tion reagents for MODULRA E170 electrochemical luminescence analyzer is excellent ,and it can meet the needs of clinical diagnosis and treatment .

Short-term outcome of the acellular dermal matrix in dental implant surgical sites / 中华口腔医学杂志

<p><b>OBJECTIVE</b>To evaluate the clinical short-term results of the acellular dermal matrix for guided bone regeneration.</p><p><b>METHODS</b>Sixty-four patients with bone defect in anterior maxillary area (average bone width: 3 mm) were included. Ridge-splitting technique with simultaneous placement of implants and artificial bone material implantation was performed in 21 patients (non-membrane group). Forty-three patients received the same procedure but with acellular dermal matrix covering the surgical sites (membrane group). The patients were followed up for three months and the new bone formation was checked in clinic and by X-ray.</p><p><b>RESULTS</b>Three months after operation, the membrane group showed good osseointegration and high bone density over the implant cover screws. In the second operation, the membranes became thinner and the new bone fully covered the implant in the membrane group. The labial bone exhibited slight absorption and labial surface of 7 implants in 7 patients was exposed in non-membrane group. The width and the height of the ridge in the second operation were greater in membrane group than in non-membrane group (P < 0.05).</p><p><b>CONCLUSIONS</b>The acellular dermal matrix can effectively resist the growth of soft tissue to allow bone regeneration around the implant.</p>

Integrative construction of animal health systems and public health / 中国兽医学报

Animal health systems initially established in Australia,Canada and other countries,played a very important role in prevention and control of animal diseases.Based on comparing the animal health systems of Australia with the veterinary medical system in China,some strategies was obtained for establishing a more reasonable official veterinary system and animal health system in China,thus speeding up the integration process of veterinary and human medical public health system.

Study on the mechanism of acupoint sticking therapy with Chuan fuling for treatment of asthma model rats / 中国针灸

<p><b>OBJECTIVE</b>To investigate the mechanism of the acupoint sticking therapy with Chuanfuling for preventing and treating asthma.</p><p><b>METHODS</b>Thirty male SD rats were randomly divided into a control group (normal saline, p.i. +no acupoint sticking+ normal saline, spray inhalation), model group (normal saline with ovalbumin, p.i. +no acupoint sticking+ normal saline with ovalbumin, spray inhalation), and acupoint sticking group (normal saline with ovalbumin, p.i. +acupoint sticking with Chuan fuling+normal saline with ovalbumin, spray inhalation), 10 rats in each group. The incubation period of nodding breath, symptom of asthmatic attack, expression level of interleukin-4 mRNA (IL-4 mRNA) and interferon-gamma mRNA (IF-gamma mRNA), as well as pathological changes on the middle leaf of right lung, were observed in each group.</p><p><b>RESULTS</b>(1) Comparing with the control group, the model group was showed that the expression level of IL-4 mRNA in the peripheral blood cells (PBMC) was increased, while hyperemia, edema and eosinocyte (EOS) invasion of lung tissue was more serious (P < 0.01). (2) Comparing with the model group, the acupoint sticking group was showed that the expression level of IL-4 mRNA in PBMC was decreased, the incubation period of nodding breath was prolonged for induced asthma on the fifth and seventh time with lower frequency, while in the lung tissue EOS invasion was reduced (P < 0.05), but there were no significant changes on the hyperemia and edema (P > 0.05).</p><p><b>CONCLUSION</b>Acupoint sticking for treating asthma of model rats with Chuanfuling can inhibit the expression level of IL-4 mRNA in PBMC, and the release of the inflammatory mediator and cytokine from the EOS to the air passage, in order to reduce the injury of epithelial layer and high reaction on the air passage.</p>

Progress in research and application of bioactive scaffolds in bone tissue engineering / 中华创伤骨科杂志

The research on novel scaffold materials is now characterized by a transition from single element to composition, from inert materials to bioactive materials, and from macro- level to micro- level. With the rapid development of nano- technology and life sciences, the two concepts of nano- modification and biomimic construction joined the mainstream of the scaffold research. And in this field, the theory of bone generation net has been recently explored systematically and comprehensively. As a result, it has now become a research focus to obtain ideal bioactive scaffolds on the basis of current investigation. This paper highlights several types of promising scaffolds, discusses their recent research and application, and reviews the present situation concerning bioactive scaffolds

Experimental Study of Intervention of Yiqi Huaxian Decoction on Rats Pulmonary Fibrosis / 广州中医药大学学报

Objective To observe the effect of Yiqi Huaxian Decoction (YHD) on transforming growth factor ?1(TGF-?1 )mRNA expression in rats alveolar macrophages (AM) and pulmonary interstitial macrophages (IM).Methods Ninety-six Wistar rats were randomized into sham-operation group,model group,YHD (4 g?kg-1?d-1) group,and hydrocortisone (20 mg?kg-1?d-1) group.Bleomycin A5 was injected into the rats' trachea to induce pulmonary fibrosis.AM and IM were isolated for the culturing after modeling for 7 and 28 days.Molecular in-situ hybridization (ISH) was used for the detection of TGF-?1 expression in AM and IM.Results Percentage of cells in AM and IM with TGF-?1 positive expression and the score of optic density were increased in the model group (P